Keep Trying

Posted on: 04 April 2008 by Gareth Hargreaves

A new study in the States has found that all may not be lost for men who fail to gain an erection using Viagra.

A new study in the States has found that all may not be lost for men who fail to gain an erection using Viagra.

The study, conducted by Columbia University Medical Centre in New York, found that a combination of an erection pill such as Viagra and testosterone gel may benefit men who fail treatment with the pill alone, suggesting that men with sexual dysfunction should be screened for low testosterone.

The combined treatment of Viagra and AndroGel (testosterone gel) was found to improve erectile function and overall sexual satisfaction, according to Dr. Ridwan Shabsigh, the lead investigator in the study, which was published in the August issue of the Journal of Urology.

"Our data support the potential benefits of a combination therapy with testosterone gel for men with erectile dysfunction and low testosterone who find sildenafil by itself ineffective," said Dr. Shabsigh. "When assessing erectile dysfunction, doctors and patients should consider using a simple blood test to determine if low testosterone is a contributing factor. If the root cause is low testosterone, sildenafil alone won't fix the problem."

It is estimated that four to five million American men have low testosterone. Furthermore, low testosterone, also called hypogonadism or "low T," affects about one in 10 men between the ages of 40 and 60. Low testosterone may lead to decreased libido, erectile dysfunction, osteoporosis, reduced lean body mass, depressed mood and fatigue.

Sildenafil enhances the effects of nitric oxide, a chemical in the body that allows increased blood flow to the penis during sexual stimulation. "Research suggests nitric oxide may be dependent on testosterone to function properly," says Dr. Shabsigh. "While further studies are needed, this concept may explain why testosterone replacement therapy could help hypogonadal men who do not respond to sildenafil."

In the trial, 75 hypogonadal men (18 to 80 years old) were randomised to testosterone gel plus sildenafil versus placebo plus Viagra. Participants were in a stable heterosexual relationship. Ninety-one percent had experienced erectile dysfunction for at least one year prior to the study. All participants had testosterone levels in the low to low/normal range and had failed to respond to 100mg doses of Viagra. At the end of the study it was apparent that the majority of the participants benefitted most from a combination of testosterone gel and viagra to achieve more satisfactory erections.

Share with friends


You need to be signed in to rate.